The APVMA commenced the review of fipronil in September 2003. The initial review considered:
- concerns over toxicity, primarily related to skin irritation and skin sensitisation
- the potential for fipronil to form toxic photodegradation products
- occupational health and safety issues
- animal safety
- the adequacy of label instructions.
In 2006, new information from international regulatory authorities was identified showing that fipronil and its metabolites are very highly toxic to organisms in the environment, particularly aquatic and terrestrial insects. As a result, the APVMA extended the scope of the fipronil review in August 2012 to include environmental considerations.