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This publication provides a summary of the data reviewed and an outline of the regulatory considerations for the proposed registration of BION PLANT ACTIVATOR SEED TREATMENT, which contains the new active constituent acibenzolar-S-methyl. The product is proposed to be used for the protection of cotton in supressing fusarium wilt (Fusarium oxysporum f.sp. vasinfectum) and black root rot (Thielaviopsis basicola), by activating the plant’s natural resistance mechanisms, when applied as a seed treatment and used as a component of an integrated management strategy.