In January 2000, the APVMA (then known as NRA) released a Chlorpyrifos interim review report which summarised the outcomes of interim chemistry, agricultural, toxicological, occupational health and safety and environmental assessment reports. The report found that some home and garden formulations of chlorpyrifos could pose an unacceptable health and safety risk and that there were potential environmental concerns, particularly for birds and fish. As a result, several regulatory measures were implemented including label amendments with updated directions for use, first aid and safety directions, and environmental warning statements.
The interim review report also found that there were inadequate data to support several uses of chlorpyrifos. Additional residues data subsequently submitted to the APVMA formed the basis of a preliminary review findings report on additional residues data (2009) recommending further label amendments and the establishment of permanent maximum residue limits (MRLs) in the MRL Standard.
In April 2017, the APVMA finalised the supplementary toxicology assessment report considering new studies published between 2000 and 2016 on developmental and behavioural neurotoxicity of chlorpyrifos.
The supplementary toxicology assessment found no evidence to indicate potential neurodevelopment effects to occur at or below doses of chlorpyrifos that are used to establish the acceptable daily intake (ADI) and acute reference dose (ARfD). The current ADI of 0.003 mg/kg bw/d, ARfD of 0.1 mg/kg bw and the poison schedule (Schedule 6) for chlorpyrifos remain appropriate.
Chemical Reviews (reconsiderations) are dynamic and our work plans must be flexible to consider:
- new scientific information
- our response to emerging issues that may need regulatory action to address.
The Chlorpyrifos work plan has been reviewed and updated in line with the legislation and associated regulations. We have received additional assessment data from approval and registration holders since the review started on 1 July 2015, so the modular assessment levels in this work plan have been adjusted.
The Chlorpyrifos review scope and work plan has been adjusted to include a residues level 5.2 assessment (previously a level 5.4) and environment level 7.1 assessment (previously a level 7.2). The recalculated timeframe for the Chlorpyrifos Review is 37 months. We expect the review findings and proposed recommendations to be available for public comment in August 2018.