Macrocyclic lactones Chemical Review

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Macrocyclic lactones are anthelmintic parasiticides that are widely used in Australia and elsewhere to treat livestock.

Macrocyclic lactones are natural fermentation products of the fungus-like Streptomyces bacterium. They are administered to grazing livestock as oral drenches or as topical and injectable formulations, mainly to control gastrointestinal nematode parasites but also to help control several external parasites, including buffalo fly, cattle tick and lice. An intra-ruminal bolus formulation is also available for sheep.

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