In April 1991, the National Health and Medical Research Council (NHMRC) advised the Australian Agricultural and Veterinary Chemicals Council of concerns about the lack of toxicological data for metoxuron.
The NHMRC began a reconsideration of metoxuron in 1991 and requested more information from its registrants. The registrants failed to provide more information to support the existing maximum residue limits (MRLs), and in 1993 the NHMRC placed metoxuron in Appendix M of the Standard for the Uniform Scheduling of Drugs and Poisons, which included ‘substances for which registration cannot be supported by scheduling until further toxicological information becomes available’.
The primary registrant, Cropcare, voluntarily ceased local manufacture of all products containing metoxuron in 1989 and the sale of stocks by 1992. The product registrations were not renewed and field stocks were negligible by 1994.
In January 1994, the APVMA began a special review of metoxuron to formally consolidate the previous regulatory actions of the NHMRC and the Australian Agricultural and Veterinary Chemicals Council.
In January 1994, the APVMA (formerly the NRA) began a special review of metoxuron because of concerns over a lack of toxicological data.