Nicarbazin chemical review


Nicarbazin is a coccidiostat that is mixed with feed for broiler chickens for the prevention and control of coccidiosis caused by Eimeria spp. Coccidiosis is a common disease of poultry and can result in a high death rate.

Nicarbazin is a 1:1 molar mixture of 4,4'-dinitrocarbanilide (DNC) and 4,6-dimethyl-2-hydroxypyrimidine (HDP). On a weight/weight basis, DNC makes up 70.9 per cent of nicarbazin. After oral ingestion, the complex dissociates to DNC and HDP and both components undergo metabolism via different routes and at different rates.

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