Nicarbazin Chemical Review

Completed

Nicarbazin is a coccidiostat that is mixed with feed for broiler chickens for the prevention and control of coccidiosis caused by Eimeria spp. Coccidiosis is a common disease of poultry and can result in a high death rate.

Nicarbazin is a 1:1 molar mixture of 4,4'-dinitrocarbanilide (DNC) and 4,6-dimethyl-2-hydroxypyrimidine (HDP). On a weight/weight basis, DNC makes up 70.9% of nicarbazin. After oral ingestion, the complex dissociates to DNC and HDP and both components undergo metabolism via different routes and at different rates.

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